AffiKIT® DNA Double Strand Break (DSB) Staining Kit, Trial Size

https://www.affikit.com/web/image/product.template/688451/image_1920?unique=53ffaba

CAT# AFG-CBL-235
Size: 20 Assays

290.25 290.25 USD 290.25

290.25

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Overview

Double-strand breaks (DSB) in DNA are among the most dangerous types of DNA damage occuring within cells. One of the earliest cellular responses to double-strand breaks is the phosphorylation of a histone variant, H2AX, at the sites of DNA damage. Within seconds Ser139 is phosphorylated when DSBs are induced in mammalian cells. Phosphorylation of this serine residue causes chromatin condensation and appears to play a critical role in the recruitment of repair or damage-signaling factors to the DNA damage sites. The DNA Double-Strand Break Staining Kit provides an easy-to-use method for detecting the presence of DSBs in cells cultured in microtiter plates. Double strand breaks can be detected in just a few hours by immunofluorescence staining of the phosphorylated histone H2AX.

Product Line

Oxidative Stress/Damage.

Host

N/A.

Species Reactivity

N/A.

Shipping Temperature

Blue Ice.

Product Classification

Oxidative Stress/ Damage; DNA / RNA Damage and Repair; DNA Double-Strand Break Assay.

Detection Method

Immunofluorescence.

Application

N/A.

Storage Temperature

-20ºC